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These symptoms can begin as early as 6–18 months of age [63]

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This could involve strategies to induce immunogenic cell death that activates an immune response against dead-cell antigens and can enhance the efficacy of treatments such as chemotherapy and radiation by stimulating the immune system to target tumor cells and overcome the immunosuppressive TME which refers to the local environment surrounding a tumor that is modified by cancer cells to evade the immune system's attack, thereby promoting tumor growth and survival by preventing an effective anti-tumor immune response